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These activations trigger the synthesis of cytokines and other inflammatory substances that worsen the damage to neurons, therefore contributing to the death of neurons and the advancement of neurodegenerative disorders (Mesci et al., 2024)

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7 Conclusion PYY, a hormone derived from the intestine, has developed from being originally considered a simple anorexic peptide to a core participant in our understanding of the intestinal-brain-peripheral metabolic axis regulation network